Glutathione Dynamics in the Tumor Microenvironment: A Potential Target of Cancer Stem Cells and T Cells
Y. Park, Eui Man Jeong
Abstract
Glutathione (GSH), the main cellular antioxidant, dynamically influences tumor growth, metastasis, and resistance to therapy in the tumor microenvironment (TME), which comprises cancer cells, immune cells, stromal cells, and non-cellular components, including the extracellular matrix, metabolites, hypoxia, and acidity. Cancer stem cells (CSCs) and T cells are minor but significant cell subsets of the TME. GSH dynamics influences the fate of CSCs and T cells. Here, we explored GSH dynamics in CSCs and T cells within the TME, as well as therapeutic approaches that could target these dynamics.
Topics & Concepts
Tumor microenvironmentCancer stem cellStromal cellCancer cellGlutathioneStem cellCancer researchCell biologyChemistryExtracellular matrixImmune systemMetastasisBiologyCancerTumor cellsImmunologyBiochemistryEnzymeGeneticsImmune cells in cancerEpigenetics and DNA MethylationSulfur Compounds in Biology