Exosome-Mediated Transfer of circ_0000338 Enhances 5-Fluorouracil Resistance in Colorectal Cancer through Regulating MicroRNA 217 (miR-217) and miR-485-3p
Kui Zhao, Xiaohui Cheng, Zhenyu Ye, Yecheng Li, Wei Peng, Yongyou Wu, Chungen Xing
Abstract
Besides that, the exosomal circ_0000338 concentration was higher in patients exhibiting resistance to 5-FU and showed good diagnostic efficiency in 5-FU-resistant CRC. The delivery of circ_0000338 via exosomes enhanced 5-FU resistance in CRC through negative regulation of miR-217 and miR-485-3p, indicating a promising diagnostic and therapeutic marker for 5-FU-based chemotherapy in CRC patients.
Topics & Concepts
MicrovesiclesExosomeGene knockdownFlow cytometrymicroRNABiologyApoptosisMolecular biologyCell growthDownregulation and upregulationBlotWestern blotCancer researchBiochemistryGeneCircular RNAs in diseasesMicroRNA in disease regulationCancer-related molecular mechanisms research