Porphyrin and doxorubicin mediated nanoarchitectonics of copper clusters: a bimodal theranostics for cancer diagnosis and treatment <i>in vitro</i>
Merin Joseph, Muhammed Shafeeque Rahman Pathiripparambath, Vinoy Thomas, Hanas Tharayil, Ramapurath S. Jayasree, Lakshmi V. Nair
Abstract
protoporphyrin IX (PPIX) and doxorubicin (Dox) is demonstrated as the functional material. Dox-loaded porphyrin-mediated CuC assembly shows singlet oxygen generation and 66% drug release at 15 min. Furthermore, the efficacy of this material is tested for cancer diagnosis and bimodal therapeutic strategy due to the fluorescing ability of the cluster and loading of PPIX as well as the drug, respectively. The nanoarchitecture exhibits targeted imaging and 83% cell death in HeLa cells upon laser irradiation with 10 nmoles and 20 nmoles of PPIX and Dox, respectively.
Topics & Concepts
PorphyrinHeLaSinglet oxygenDoxorubicinMaterials sciencePhotodynamic therapyNanotechnologyDrug deliveryCancer cellNanoparticleBiophysicsIn vitroCancerChemistryBiochemistryMedicineOxygenChemotherapyOrganic chemistryBiologySurgeryInternal medicineNanocluster Synthesis and ApplicationsAdvanced Nanomaterials in CatalysisNanoplatforms for cancer theranostics