Dual functional cholinesterase and carbonic anhydrase inhibitors for the treatment of Alzheimer's disease: Design, synthesis, in vitro, and in silico evaluations of coumarin-dihydropyridine derivatives
Nawrooz Ali Zahedi, Maryam Mohammadi‐Khanaposhtani, Parisa Rezaei, Mohammad Askarzadeh, Majid Alikhani‐Koupaei, Mehdi Adib, Mohammad Mahdavi, Bagher Larijani, Somayeh Niakan, Maliheh Barazandeh Tehrani, Parham Taslımı, İlhami Gülçın
Topics & Concepts
ChemistryButyrylcholinesteraseCarbonic anhydrasePharmacophoreIn silicoCoumarinCholinesterasePharmacologyAcetylcholinesteraseTacrineOxadiazoleIn vitroEnzymeBiochemistryAchéMedicineOrganic chemistryGeneCholinesterase and Neurodegenerative DiseasesEnzyme function and inhibitionChemical synthesis and alkaloids