A New Comorbidity in Periodontitis: Fusobacterium nucleatum and Colorectal Cancer
Francisco Mesa, María José Mesa-López, J. Egea Valenzuela, Cristina Benavides‐Reyes, Luigi Nibali, Mark Ide, Giuseppe Mainas, Manfredi Rizzo, Antonio Magán‐Fernández
Abstract
There is very recent and strong evidence relating Fusobacterium nucleatum to colorectal cancer. In this narrative review, we update the knowledge about gingival dysbiosis and the characteristics of Fusobacterium nucleatum as one of the main bacteria related to periodontitis. We provide data on microbiome, epidemiology, risk factors, prognosis, and treatment of colorectal cancer, one of the most frequent tumours diagnosed and whose incidence increases every year. We describe, from its recent origin, the relationship between this bacterium and this type of cancer and the knowledge and emerging mechanisms that scientific evidence reveals in an updated way. A diagram provided synthesizes the pathogenic mechanisms of this relationship in a comprehensive manner. Finally, the main questions and further research perspectives are presented.