Iron-Catalyzed Regioselective Reductive Fluoroalkylalkenylation of Unactivated Alkenes
Siyu Wang, Bohao Guo, Tong Mu, Zhengli Liu, Yun He, Xiao‐Song Xue, Feng Zhang
Abstract
The example of iron-catalyzed reductive fluoroalkylalkenylation of unactivated alkenes has been disclosed, affording the stereodefined homoallylic fluoroalkanes with high efficiency and regioselectivity. This three-component cross-electrophile coupling features directing groups free, good functional group tolerance, broad substrate scope, and late-stage difunctionalization of biorelevant molecules. Moreover, this protocol sheds light on the distinct reactivity disparities between fluoroalkyl and nonfluoroalkyl radicals in three-component reductive cross-coupling reactions, highlighting the unique nature of iron/B 2 pin 2 systems.
Topics & Concepts
RegioselectivityElectrophileChemistryCatalysisFunctional groupSubstrate (aquarium)Reductive eliminationReactivity (psychology)Combinatorial chemistryRadicalOrganic chemistryAlternative medicinePathologyPolymerOceanographyGeologyMedicineFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsRadical Photochemical Reactions