Dysregulation of hsa-miR-34a and hsa-miR-449a leads to overexpression of PACS-1 and loss of DNA damage response (DDR) in cervical cancer
Mysore S. Veena, Santanu Raychaudhuri, Saroj K. Basak, Natarajan Venkatesan, Parameet Kumar, Roopa Biswas, Rita Chakrabarti, Jing Lü, Trent Su, Marcus Gallagher-Jones, Marco Morselli, Haiqing Fu, Matteo Pellegrini, Theodore C. Goldstein, Mirit I. Aladjem, Matthew B. Rettig, Sharon P. Wilczynski, Daniel Sanghoon Shin, Eri S. Srivatsan
Abstract
-S phase of the cell cycle. Our results therefore indicate that the loss of hsa-miR-34a and hsa-miR-449a expression in cervical cancer leads to overexpression of PACS-1 and suppression of DNA damage response, resulting in the development of chemo-resistant tumors.
Topics & Concepts
microRNAHeLaDNA damageTransfectionCancer researchMolecular biologyBiologyCell cultureCell cycleBlotCell growthCell cycle checkpointCellDNAGeneGeneticsMicroRNA in disease regulationRNA Research and SplicingRNA modifications and cancer