A Phase I Trial of IGF-1R Inhibitor Cixutumumab and mTOR Inhibitor Temsirolimus in Metastatic Castration-resistant Prostate Cancer
Deaglan Joseph McHugh, Jay Chudow, Mia DeNunzio, Susan F. Slovin, Daniel C. Danila, Michael J. Morris, Howard I. Scher, Dana E. Rathkopf
Topics & Concepts
TemsirolimusMedicineDiscovery and development of mTOR inhibitorsProstate cancerCastrationOncologyInternal medicinePI3K/AKT/mTOR pathwayCancerApoptosisHormoneBiochemistryChemistryPI3K/AKT/mTOR signaling in cancerProstate Cancer Treatment and ResearchBone health and treatments