Comparison of an Affibody-based Molecular Probe and <sup>18</sup>F-FDG for Detecting HER2-Positive Breast Cancer at PET/CT
Xiaoyi Guo, Nina Zhou, Jiayue Liu, Jin Ding, Teli Liu, Guohong Song, Hua Zhu, Zhi Yang
Abstract
In participants with human epidermal growth factor receptor 2–positive breast cancer, the affibody-based tracer Al 18 F-NOTA-HER2-BCH enabled detection of more primary lesions and lymph node, bone, and liver metastases than fluorine 18 fluorodeoxyglucose on PET/CT images.
Topics & Concepts
MedicineNuclear medicineBreast cancerPositron emission tomographyCancerOncologyCancer researchInternal medicineMonoclonal and Polyclonal Antibodies ResearchAdvanced Biosensing Techniques and ApplicationsRadiopharmaceutical Chemistry and Applications