A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome
Gennaro Napolitano, Chiara Di Malta, Alessandra Esposito, Mariana E. G. de Araújo, Salvatore Pece, Giovanni Bertalot, Maria Matarese, Valerio Benedetti, Angela Zampelli, Taras Stasyk, Diletta Siciliano, Alessandro Venuta, Marcella Cesana, Claudia Vilardo, Edoardo Nusco, Jlenia Monfregola, Alessia Calcagnì, Pier Paolo Di Fiore, Lukas A. Huber, Andrea Ballabio
Topics & Concepts
FolliculinTFEBBirt–Hogg–Dubé syndromemTORC1RHEBCell biologyBiologyP70-S6 Kinase 1Cancer researchPhosphorylationMechanistic target of rapamycinProteostasisPI3K/AKT/mTOR pathwayChemistryTranscription factorSignal transductionGeneticsGeneAnatomyPneumothoraxRenal cell carcinoma treatmentRenal Diseases and GlomerulopathiesTuberous Sclerosis Complex Research