Nucleolar protein NOP2 could serve as a potential prognostic predictor for clear cell renal cell carcinoma
Gang Wang, Fangfang Qu, Shouyong Liu, Jincai Zhou, Yi Wang
Abstract
< 0.05). Univariate/multivariate Cox hazard regression analysis results indicated that NOP2 was an independent prognostic factor for OS in ccRCC and GSEA revealed five NOP2-related signaling pathways. Nomogram based on NOP2 and eight clinical characteristic parameters (grade, age, stage, gender, T stage, race, M stage, N stage) was constructed and carefully evaluated. Furthermore, NOP2 gene expression was also found to be significantly related to MSI, TMB, and immunity. Our findings revealed that NOP2 might be a potential prognostic factor for OS in ccRCC and it was significantly associated with immunity, MSI, and TMB.
Topics & Concepts
Clear cell renal cell carcinomaOncologyStage (stratigraphy)Internal medicineProportional hazards modelRenal cell carcinomaMedicineNomogramBiologyKidney cancerUnivariate analysisCancerCancer researchMultivariate analysisPaleontologyFerroptosis and cancer prognosisRNA modifications and cancerCancer-related molecular mechanisms research