Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity
Yao Hong, Minghui Liu, Leibo Wang, Yumeng Zu, Chou Wu, Chenyu Li, Ruoxi Zhang, Haigen Lu, Feifei Li, Shuang Xi, Shuangquan Chen, Xuanyu Gu, Tianya Liu, Jie Cai, Shirong Wang, Maojun Yang, Guo‐Gang Xing, Wei Xiong, Lan Hua, Yefeng Tang, Gelin Wang
Topics & Concepts
Nicotinamide phosphoribosyltransferaseNAD+ kinaseNeuroprotectionNicotinamide adenine dinucleotideBiologyNeurodegenerationPhosphoribosyltransferaseBiochemistryNatAllosteric regulationPharmacologyEnzymeCell biologyHypoxanthine-guanine phosphoribosyltransferaseDiseaseMutantMedicineComputer networkGeneComputer sciencePathologySirtuins and Resveratrol in MedicineCalcium signaling and nucleotide metabolismPARP inhibition in cancer therapy