Antioxidant, Anti‐Inflammatory, and Antidiabetic Activities of Bioactive Compounds from the Fruits of <i>Livistona chinensis</i> Based on Network Pharmacology Prediction
Yuwei Wang, Jianxiu Zhai, Dan Yang, Na Han, Zhe Liu, Zhihui Liu, Sikai Li, Jun Yin
Abstract
In this study, a chemical investigation on the fruits of Livistona chinensis (FLC) led to the isolation and identification of 45 polyphenols and 5 alkaloids, including two new compounds (Livischinol (1) and Livischinine A (46)), an undescribed compound (47) and 47 known compounds. FLC was predicted with novel potential antidiabetic function by collecting and analyzing the potential targets of the ingredients. Compound 32 exhibited significant α ‐glucosidase inhibitory activity (IC 50 = 5.71 μ M) and 1, 6, and 44 showed the PTP1B inhibitory activity with IC 50 values of 9.41‐22.19 μ M, while that of oleanolic acid was 28.58 μ M. The competitive inhibitors of PTP1B (compounds 1 and 44) formed strong binding affinity, with catalytic active sites, proved by kinetic analysis, fluorescence spectra measurements, and computational simulations, and stimulated glucose uptake in the insulin‐resistant HepG2 cells at the dose of 50 μ M. In addition, FLC was rich in antioxidant and anti‐inflammatory bioactive compounds so that they could be developed as nutraceuticals against diabetes.