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Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production

Joshua T. Weinreb, Noura Ghazale, Kith Pradhan, Varun Gupta, Kathryn Potts, Brad Tricomi, Noah J. Daniels, Richard A. Padgett, Sofía de Oliveira, Amit Verma, Teresa V. Bowman

2021Developmental Cell128 citationsDOIOpen Access PDF

Topics & Concepts

BiologyCell biologyHaematopoiesisProgenitor cellZebrafishInnate immune systemProgenitorMutantStem cellImmunologyImmune systemGeneticsGeneinterferon and immune responsesMosquito-borne diseases and controlZebrafish Biomedical Research Applications