Selective Buchwald–Hartwig arylation of<i>C</i>-amino-1,2,4-triazoles and other coordinating aminoheterocycles enabled by bulky NHC ligands and TPEDO activator
Alexander V. Astakhov, Andrey Yu. Chernenko, Vadim V. Kutyrev, Gleb S. Ranny, Mikhail E. Minyaev, Victor M. Chernyshev, Valentine P. Ananikov
Abstract
A facile method for selective N-(hetero)arylation of coordinating 3(5)-amino-1,2,4-triazoles under Pd/NHC catalysis using TPEDO as a new efficient Pd( ii ) to Pd(0) reductant has been developed.
Topics & Concepts
ChemistryCatalysisActivator (genetics)Combinatorial chemistryStereochemistryMedicinal chemistryOrganic chemistryReceptorBiochemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsN-Heterocyclic Carbenes in Organic and Inorganic Chemistry