A light-induced small G-protein gem limits the circadian clock phase-shift magnitude by inhibiting voltage-dependent calcium channels
Masahiro Matsuo, Kazuyuki Seo, Akiyuki Taruno, Yasutaka Mizoro, Yoshiaki Yamaguchi, Masao Doi, Rhyuta Nakao, Hiroshi Kori, Takaya Abe, Harunori Ohmori, Keiko Tominaga, Hitoshi Okamura
Abstract
mice. Our findings suggest that transcriptionally activated Gem feeds back to suppress excessive light-evoked L-type VDCC activation, adjusting the light-induced phase-shift magnitude to an appropriate level in mammals.
Topics & Concepts
Circadian rhythmCircadian clockMagnitude (astronomy)CalciumBiophysicsChemistryPhase (matter)Cell biologyPhysicsBiologyEndocrinologyQuantum mechanicsOrganic chemistryAstronomyCircadian rhythm and melatoninPhotoreceptor and optogenetics researchSpaceflight effects on biology