Ruthenium-catalyzed coupling of α-carbonyl phosphoniums with sulfoxonium ylides <i>via</i> C–H activation/Wittig reaction sequences
Tian Chen, Zhiqiang Ding, Yu‐Qiu Guan, Ruike Zhang, Jinzhong Yao, Zhangpei Chen
Abstract
A Ru(ii)-catalyzed coupling of various α-carbonyl phosphoniums with sulfoxonium ylides has been realized for the facile synthesis of 1-naphthols in good to excellent yields. This oxidant-free transformation proceeds through Ru-catalyzed C-H activation of phosphoniums, Ru-carbene insertion, and intramolecular Wittig reaction processes.
Topics & Concepts
RutheniumCatalysisWittig reactionCoupling reactionCoupling (piping)ChemistryCombinatorial chemistryPhotochemistryStereochemistryOrganic chemistryMaterials scienceMetallurgyCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesSynthesis and Catalytic Reactions