miR-1 sustains muscle physiology by controlling V-ATPase complex assembly
Paula Gutiérrez‐Pérez, Emilio M. Santillán, Thomas Lendl, Jingkui Wang, Anna Schrempf, Thomas L. Steinacker, Mila Asparuhova, Marlene Brandstetter, David Haselbach, Luisa Cochella
Abstract
. Unexpectedly, up-regulation of V-ATPase subunits upon miR-1 deletion causes reduced V-ATPase function due to defects in complex assembly. These results reveal V-ATPase assembly as a conserved muscle cell vulnerability and support a previously unknown role for microRNAs in the regulation of protein complexes.
Topics & Concepts
RegulonPhysiologyCell biologyLysosomeCell physiologyATPaseFunction (biology)MitochondrionBiologyBiochemistryRegulation of gene expressionEnzymeGeneCellATP Synthase and ATPases ResearchMitochondrial Function and PathologyRNA modifications and cancer