Acute leucoencephalomyelopathy and quadriparesis after CAR T-cell therapy
Ranjit Nair, Gaëlle Drillet, Faustine Lhomme, Anthony Le Bras, Laure Michel, John M. Rossi, Marika Sherman, Allen Xue, A. Kerber, Nutchawan Jittapiromsak, Linda Chi, Sudhakar Tummala, Sattva S. Neelapu, Roch Houot
Abstract
Chimeric antigen receptor (CAR) T-cell therapy maybe associated with neurologic toxicity, also referred to as immune effector cell-associated neurotoxicity syndrome (ICANS), 1,2 that typically manifests as encephalopathy.
Topics & Concepts
Political scienceHumanitiesMedicinePhilosophyCAR-T cell therapy researchBiomedical Ethics and RegulationVirus-based gene therapy research