MicroRNA-155 Deficiency Exacerbates Trypanosoma cruzi Infection
Bijay Kumar Jha, Sanjay Varikuti, Gabriella R. Seidler, Greta Volpedo, Abhay R. Satoskar, Bradford S. McGwire
Abstract
Chagas disease, caused by the intracellular protozoan parasite Trypanosoma cruzi , is a public health problem affecting 6 to 8 million people, mainly in Latin America. The role of microRNAs in the pathogenesis of Chagas disease has not been well described. Here, we investigate the role of microRNA-155 (miR-155), a proinflammatory host innate immune regulator responsible for T helper type 1 and type 17 (Th1 and Th17) development and macrophage responses during T. cruzi infection.
Topics & Concepts
Trypanosoma cruziBiologyChagas diseaseImmunologymiR-155KinetoplastidaImmune systemProinflammatory cytokinePathogenesisTrypanosomaInnate immune systemmicroRNARegulatorVirologyParasite hostingInflammationProtozoal diseaseGeneGeneticsMalariaComputer scienceWorld Wide WebTrypanosoma species research and implications