Anesthesia and surgery induce a functional decrease in excitatory synaptic transmission in prefrontal cortex neurons, and intraoperative administration of dexmedetomidine does not elicit the synaptic dysfunction
Yu Matsumoto, Yuji Fujino, Hidemasa Furue
Topics & Concepts
DexmedetomidineExcitatory postsynaptic potentialNeurotransmissionAnesthesiaNeuroscienceInhibitory postsynaptic potentialIsofluraneMedicinePrefrontal cortexPsychologyCognitionInternal medicineSedationReceptorIntensive Care Unit Cognitive DisordersAnesthesia and Neurotoxicity ResearchAnesthesia and Sedative Agents