pH-triggered degradation and release of doxorubicin from zeolitic imidazolate framework-8 (ZIF8) decorated with polyacrylic acid
Vy Anh Tran, Sang‐Wha Lee
Abstract
release test of ZIF8-Dox@PAA at pH 7.4 showed the low release rate of 24.7% even after 100 h. However, ZIF8-Dox@PAA at pH 4.0 exhibited four stages of release profiles, significantly enhanced release rate of 84.7% at the final release stage after 30 h. The release kinetics of ZIF8-Dox@PAA was analyzed by the sigmoidal Hill, exponential Weibull, and two-stage BiDoseResp models. The ZIF8-Dox@PAA nanocarrier demonstrated a promising theranostic nanoplatform equipped with fluorescent bioimaging, pH-responsive controlled drug release, and high drug loading capacity.
Topics & Concepts
Polyacrylic acidZeolitic imidazolate frameworkDegradation (telecommunications)ImidazolateChemistryDoxorubicinChemical engineeringNuclear chemistryInorganic chemistryOrganic chemistryPolymerMetal-organic frameworkAdsorptionComputer scienceChemotherapyEngineeringMedicineTelecommunicationsSurgeryMetal-Organic Frameworks: Synthesis and ApplicationsNanoplatforms for cancer theranosticsAnalytical Chemistry and Sensors