The ER-associated protease Ste24 prevents N-terminal signal peptide-independent translocation into the endoplasmic reticulum in Saccharomyces cerevisiae
Akíra Hosomi, Kazuko Iida, Toshihiko Cho, Hidetoshi Iida, Masashi Kaneko, Tadashi Suzuki
Abstract
-glycosylated despite the lack of a signal peptide. These results clearly indicate that some proteins lacking a signal peptide can be translocated into the ER and that Ste24 typically suppresses this process.
Topics & Concepts
Signal peptideEndoplasmic reticulumSec61Saccharomyces cerevisiaeSecretory pathwayChromosomal translocationSecretory proteinBiologyCell biologyProtein targetingSignal recognition particleBiochemistryPeptideSignal peptidaseTransloconPeptide sequenceYeastGolgi apparatusMembrane proteinSecretionGeneMembraneEndoplasmic Reticulum Stress and DiseaseCellular transport and secretionFungal and yeast genetics research