TBAI-Catalyzed Oxidative Coupling of Benzyl Ketones to Synthesize 2,3-Diaryl-1,4-Diketones in Water
Lingkai Kong, Xueping Hu, Li‐Ping Bai
Abstract
-butyl hydroperoxide (TBHP) as an oxidant in water. This reaction affords the desired products in good to excellent yields from readily available materials, with a broad substrate scope, good functional group tolerance, and mild reaction conditions. Furthermore, tetrasubstituted furan and pyrrole were smoothly constructed from α-methylene ketones in one pot with 96 and 90% yields, respectively.
Topics & Concepts
FuranCatalysisMethyleneSubstrate (aquarium)ChemistryPyrroleFunctional groupOxidative coupling of methaneOrganic chemistryMedicinal chemistryReaction conditionsKetoneCombinatorial chemistryPolymerOceanographyGeologyOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization MethodsSynthesis and Characterization of Pyrroles