DNA methylation at a nutritionally sensitive region of the <i>PAX8</i> gene is associated with thyroid volume and function in Gambian children
Toby Candler, Noah J. Kessler, Chathura Gunasekara, Kate A. Ward, Philip James, Eleonora Laritsky, Maria S. Baker, Roger Dyer, Rajavel Elango, David Jeffries, Robert A. Waterland, Sophie E. Moore, Marian Ludgate, Andrew M. Prentice, Matt J. Silver
Abstract
gene methylation and thyroid gland development and function, with potential implications for early embryonic programming of thyroid-related health and disease.
Topics & Concepts
PAX8DNA methylationGeneMethylationThyroid functionFunction (biology)EpigeneticsDNABiologyThyroidGeneticsMedicinePhysiologyEndocrinologyGene expressionTranscription factorEpigenetics and DNA MethylationDigestive system and related healthBirth, Development, and Health