SLC25A33-mediated mitochondrial DNA synthesis plays a critical role in the inflammatory response of M1 macrophages by contributing to mitochondrial ROS and VDAC oligomerization
Daehoon Kim, Jonghwa Jin, Yu Rim Lee, Dongho Kim, Soo Young Park, Jun‐Kyu Byun, Yeon‐Kyung Choi, Keun‐Gyu Park
Abstract
sepsis models, as well as in septic patients with liver abscesses. Our findings underscore the significant role of SLC25A33 in inflammation, suggesting that targeting of SLC25A33 could be a promising therapeutic strategy for the management of M1 macrophage-mediated inflammatory diseases, including sepsis.
Topics & Concepts
Mitochondrial DNAInflammatory responseMitochondrionCell biologyMitochondrial ROSVoltage-dependent anion channelChemistryInflammationBiologyBiochemistryImmunologyBacterial outer membraneGeneEscherichia coliImmune cells in cancerTryptophan and brain disordersEicosanoids and Hypertension Pharmacology