Nanochemical electrochemical sensors and a method called as say sandwich component Three
Afshin Rashid
Abstract
Note: Signal measurement Electrochemical methods are very suitable for detecting direct DNA oxidation because electrochemical reactions directly generate electronic signals and therefore do not require expensive converters.In addition, in this process, because the order of the immobilized game can be limited to only a series of electrode substrates, the act of tracking is performed by a series of inexpensive electrochemical analyzes. Electrochemical sensors are used to perform clinical or environmental tests; The basis of the sensitivity of electrochemical signals to direct oxidation or interval catalysis of DNA is also based on the reduction reactions of reporter molecules or enzymes. Various methods are used to measure the signal electrochemically. The basis of signal measurement in direct DNA electrochemistry is based on the oxidation reaction and DNA reduction in a mercury electrode, so the amount of oxidized and reduced DNA is proportional to the amount of DNA that is hybridized with the probe. In addition to the old methods of direct DNA reduction, a method called Stripping Adsorption Voltammetry is used for direct oxidation of DNA, which is a very sensitive method. In the direct electrochemical method, purine is oxidized by materials such as carbon, indiomethin oxide (ITO), gold, and polymer-coated electrodes. Although the direct electrochemical method is a very sensitive method, its application is complex because for direct oxidation of DNA, a high potential ground current is required. Advanced mathematical and numerical methods are also needed to measure each signal. Of course, new methods have been designed to eliminate the interference that occurs in the field with the help of physical methods.