Efficient <i>O</i>- and <i>S</i>-glycosylation with <i>ortho</i>-2,2-dimethoxycarbonylcyclopropylbenzyl thioglycoside donors by catalytic strain-release
Han Ding, Jian Lv, Xiao-Lin Zhang, Yuan Xu, Yuhan Zhang, Xue‐Wei Liu
Abstract
An efficient glycosylation reaction utilizing a meticulously designed thioglycoside has been developed. The well-established protocol was demonstrated in the total synthesis of TD139 and a one-pot assembly of E. coli O33 antigen tetrasaccharide.
Topics & Concepts
GlycosylationStrain (injury)CatalysisChemistryStereochemistryBiochemistryMedicineInternal medicineCarbohydrate Chemistry and SynthesisGlycosylation and Glycoproteins ResearchPolyamine Metabolism and Applications