Antibiotics and Antibiotic Resistance—Mur Ligases as an Antibacterial Target
Vincent Hervin, Vincent Roy, Luigi A. Agrofoglio
Abstract
The emergence of Multidrug Resistance (MDR) strains of bacteria has accelerated the search for new antibacterials. The specific bacterial peptidoglycan biosynthetic pathway represents opportunities for the development of novel antibacterial agents. Among the enzymes involved, Mur ligases, described herein, and especially the amide ligases MurC-F are key targets for the discovery of multi-inhibitors, as they share common active sites and structural features.
Topics & Concepts
AntibioticsPeptidoglycanBacteriaAntibiotic resistanceMicrobiologyAntibacterial activityBiologyMultiple drug resistanceEnzymeComputational biologyChemistryBiochemistryGeneticsAntibiotic Resistance in BacteriaCancer therapeutics and mechanismsPharmaceutical and Antibiotic Environmental Impacts