Current human brain applications and challenges of dynamic hyperpolarized carbon-13 labeled pyruvate MR metabolic imaging
Yan Li, Daniel B. Vigneron, Duan Xu
Abstract
The ability of hyperpolarized carbon-13 MR metabolic imaging to acquire dynamic metabolic information in real time is crucial to gain mechanistic insights into metabolic pathways, which are complementary to anatomic and other functional imaging methods. This review presents the advantages of this emerging functional imaging technology, describes considerations in clinical translations, and summarizes current human brain applications. Despite rapid development in methodologies, significant technological and physiological related challenges continue to impede broader clinical translation.
Topics & Concepts
NeuroimagingFunctional imagingNeuroscienceMedicineMetabolic activityMedical imagingMagnetic resonance imagingMedical physicsRadiologyPsychologyPhysiologyAdvanced NMR Techniques and ApplicationsAdvanced MRI Techniques and ApplicationsAtomic and Subatomic Physics Research