Bio-guided isolation of alpha-glucosidase inhibitory compounds from Vietnamese <i>Garcinia schomburgkiana</i> fruits: <i>in vitro</i> and <i>in silico</i> studies
Ngoc‐Hong Nguyen, Y. Thien Vu, Tuan-Dat Nguyen, Truong-Tam Cao, Huy Truong Nguyen, Thi‐Kim‐Dung Le, Jirapast Sichaem, Dinh‐Tri Mai, Tran Nguyen Minh An, Thuc‐Huy Duong
Abstract
docking was employed to predict the binding mechanism of 1-2 and 4-6 in the active site of alpha-glucosidase, suggesting their potential as promising anti-diabetic compounds. Molecular dynamic simulation was also applied to 1 to better understand its inhibitory mechanism.
Topics & Concepts
GarciniaIn silicoIn vitroVietnameseChemistryTraditional medicineAlpha (finance)Inhibitory postsynaptic potentialBiologyBiochemistryMedicinePatient satisfactionPhilosophyNeuroscienceConstruct validityLinguisticsNursingGeneNatural Compound Pharmacology StudiesCarbohydrate Chemistry and SynthesisPhytochemistry and Biological Activities