Synthesis of Sulfilimines via Selective S–C Bond Formation in Water
Yue Chen, Dongmei Fang, He-sen Huang, Xiao‐kang Nie, Shiqi Zhang, Xin Cui, Zhuo Tang, Guangxun Li
Abstract
Sulfilimines are valuable compounds both in organic synthesis and in pharmaceuticals. Here we developed a mild and simplified method for preparation of sulfilimines via selective S-C bond formation rather than traditional S-N bond formation. The method is both attractive and useful for the following reasons: it uses a readily available alkylation reagent such alkyl bromide or alkyl iodide, it uses water as solvent, it is easy to perform, and it is convenient for late-stage diversification of drugs.
Topics & Concepts
ChemistryAlkylationReagentAlkylIodideBromideCombinatorial chemistrySolventOrganic synthesisHalideOrganic chemistryCatalysisSynthesis and Catalytic ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods