Design, synthesis, and biological characterization of a new class of symmetrical polyamine-based small molecule CXCR4 antagonists
Fang Xiong, Qian Meng, Huijun Zhang, Boqiang Liang, Siyu Zhu, Juan Wang, Chaozai Zhang, Lina Huang, Xingquan Zhang, Robert T. Schooley, Jing An, Yan Xu, Ziwei Huang
Topics & Concepts
CXCR4ChemistryPolyamineSmall moleculeLigand (biochemistry)MutagenesisCXCR4 antagonistBiological activityIn vitroStereochemistryDocking (animal)Binding siteBiochemistryComputational biologyReceptorBiologyChemokineMutationGeneNursingMedicineChemokine receptors and signalingImmunotherapy and Immune ResponsesHIV Research and Treatment