Structural optimization of imidazothiazole derivatives affords a new promising series as B-Raf V600E inhibitors; synthesis, in vitro assay and in silico screening
Usama M. Ammar, Mohammed S. Abdel‐Maksoud, Eslam M.H. Ali, Karim I. Mersal, Kyung Ho Yoo, Chang‐Hyun Oh
Topics & Concepts
In silicoChemistryThiazoleIn vitroCytotoxicityEnzymeStereochemistryBiochemistryCombinatorial chemistryGeneMelanoma and MAPK PathwaysComputational Drug Discovery MethodsSynthesis and biological activity