Engineering of l-threonine aldolase for the preparation of 4-(methylsulfonyl)phenylserine, an important intermediate for the synthesis of florfenicol and thiamphenicol
Zhicheng Liu, Xi Chen, Qijia Chen, Jinhui Feng, Min Wang, Qiaqing Wu, Dunming Zhu
Topics & Concepts
ChemistryAldolase AAldol reactionStereoselectivityMutantStereochemistryGlycineEnantiopure drugBiochemistryAmino acidEnzymeCatalysisEnantioselective synthesisGeneEnzyme Catalysis and ImmobilizationChemical Synthesis and AnalysisAnalytical Chemistry and Chromatography