Potential anti-neuroinflammatory NF-кB inhibitors based on 3,4-dihydronaphthalen-1(2<i>H</i>)-one derivatives
Yue Sun, Yan-Qiu Zhou, Yin-Kai Liu, Hongqin Zhang, Gui‐Ge Hou, Qingguo Meng, Yun Hou
Abstract
may be explored as a functional anti-neuroinflammatory agent for the treatment of inflammatory diseases in the central nervous system, such as multiple sclerosis, traumatic brain injury, stroke and spinal cord injury.
Topics & Concepts
NeuroinflammationMicrogliaNF-κBPyrin domainPharmacologyChemistryLipopolysaccharideApoptosisReceptorIκBαInflammasomeNFKB1ToxicityInflammationMedicineImmunologyBiochemistryOrganic chemistryTranscription factorGeneNF-κB Signaling PathwaysImmune Response and InflammationBioactive natural compounds