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1,10-Seco-Eudesmane sesquiterpenoids as a new type of anti-neuroinflammatory agents by suppressing TLR4/NF-κB/MAPK pathways

Jiang‐Jiang Tang, Min-Ran Wang, Shuai Dong, Lan-Fang Huang, Qiu-Rui He, Jin‐Ming Gao

2021European Journal of Medicinal Chemistry37 citationsDOI

Topics & Concepts

ChemistryNeuroinflammationMicrogliaTLR4Nitric oxidePharmacologyNitric oxide synthaseMAPK/ERK pathwayNF-κBp38 mitogen-activated protein kinasesTumor necrosis factor alphaBiochemistrySignal transductionInflammationImmunologyBiologyOrganic chemistryNatural product bioactivities and synthesisPhytochemistry and Biological ActivitiesSesquiterpenes and Asteraceae Studies
1,10-Seco-Eudesmane sesquiterpenoids as a new type of anti-neuroinflammatory agents by suppressing TLR4/NF-κB/MAPK pathways | Litcius