Class C Radical SAM Methyltransferases Involved in Anaerobic Heme Degradation
Liju Mathew, Marley Brimberry, William N. Lanzilotta
Abstract
. Interestingly, evolution has come full circle, and the divergence of this protein sequence/fold has resulted in the class C radical SAM methyltransferases. Several pathogenic organisms have further adapted this fold to catalyze the anaerobic degradation of heme. In this review, we summarize what is known about the mechanism of anaerobic heme degradation and the evolutionary implications.
Topics & Concepts
MethyltransferaseDegradation (telecommunications)Anaerobic exerciseChemistryHemeBiochemistryPhotochemistryBiologyComputer scienceMethylationEnzymeDNAPhysiologyTelecommunicationsHybrid Renewable Energy SystemsMetalloenzymes and iron-sulfur proteinsCancer-related gene regulation