Salivary bacterial shifts in oral leukoplakia resemble the dysbiotic oral cancer bacteriome
Divya Gopinath, Rohit Kunnath Menon, Chong Chun Wie, Moinak Banerjee, Swagatika Panda, Deviprasad Mandal, Paresh Kumar Behera, Susanta Roychoudhury, Supriya Kheur, Michael G. Botelho, Newell W. Johnson
Abstract
: Oral bacteria may play a role in the early stages of oral carcinogenesis as a dysbiotic bacteriome is associated with oral leukoplakia and this resembles that of oral cancer more than healthy controls. Our findings may have implications for developing oral cancer prevention strategies targeting early microbial drivers of oral carcinogenesis.
Topics & Concepts
Fusobacterium nucleatumFusobacteriaLeukoplakiaCancerFusobacteriumPrevotellaBacteroidesMedicineBiologyDermatologyPorphyromonas gingivalisPeriodontitisInternal medicineGeneticsBacteriaBacteroidetes16S ribosomal RNAOral microbiology and periodontitis researchOral Health Pathology and TreatmentSalivary Gland Disorders and Functions