Catalytic regio- and stereoselective intermolecular [5+2] cycloaddition <i>via</i> conjugative activation of oxidopyrylium
Ling Zhang, Qiu Shi, Tongxiang Cao, Shifa Zhu
Abstract
A catalytic stereodivergent intermolecular [5+2] cycloaddition of maltol-type oxidopyrylium through conjugative activation was reported, which featured high stereoselectivity, good compatibility and mild conditions, providing a convenient access route to various seven-membered heterocycles in moderate to excellent yields. In addition, a discrete mechanism was proposed to illustrate the stereoselectivity.
Topics & Concepts
StereoselectivityCycloadditionIntermolecular forceCatalysisChemistryStereochemistryRegioselectivityCombinatorial chemistryOrganic chemistryMoleculeCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms