Anti-human CD117 CAR T-cells efficiently eliminate healthy and malignant CD117-expressing hematopoietic cells
Renier Myburgh, Jonathan D. Kiefer, Norman F. Russkamp, Chiara F. Magnani, Nicolás Gonzalo Núñez, Alexander Simonis, Surema Pfister, C. Matthias Wilk, Donal McHugh, Juliane Friemel, Antonia Müller, Burkhard Becher, Christian Münz, Maries van den Broek, Dario Neri, Markus G. Manz
Topics & Concepts
CD117HaematopoiesisChimeric antigen receptorCancer researchMyeloid leukemiaStem cellProgenitor cellAntigenLeukemiaImmunologyMyeloidCD34BiologyImmunotherapyCell biologyImmune systemCAR-T cell therapy researchVirus-based gene therapy researchCRISPR and Genetic Engineering