Engineering of a GSH activatable photosensitizer for enhanced photodynamic therapy through disrupting redox homeostasis
Datian Fu, Yan Wang, Lin Kaiwen, Liangjiu Huang, Xu Jin, Haimei Wu
Abstract
exhibits excellent toxicity to cancer cells, followed by inducing earlier apoptosis. Thus, our study may propose a new strategy to design an activatable photosensitizer for breaking the redox homeostasis in tumor cells.
Topics & Concepts
PhotosensitizerPhotodynamic therapyRedoxChemistryHomeostasisGlutathionePhotochemistryBiophysicsBiochemistryMedicineInorganic chemistryBiologyInternal medicineOrganic chemistryEnzymeNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesSulfur Compounds in Biology