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Self-cyclization <i>vs</i>. dimerization of <i>o</i>-alkenyl arylisocyanides: chemodivergent synthesis of quinolines and pyrrolo-fused diindoles

Jinhuan Dong, Lei Wang, Haoyue Li, Xinrong Leng, Xiao-Yu Guo, Zhongyan Hu, Xianxiu Xu

2021Organic Chemistry Frontiers22 citationsDOI

Abstract

Solvent-dependent chemoselective MBH-type self-cyclization and dimerization of <italic>o</italic>-alkenyl arylisocyanides were developed for the efficient and chemodivergent synthesis of various 3-acylquinoline and pyrrolo-fused diindole frameworks.

Topics & Concepts

ChemistrySolventCombinatorial chemistryStereochemistryMedicinal chemistryOrganic chemistryAsymmetric Synthesis and CatalysisChemical synthesis and alkaloidsAxial and Atropisomeric Chirality Synthesis
Self-cyclization <i>vs</i>. dimerization of <i>o</i>-alkenyl arylisocyanides: chemodivergent synthesis of quinolines and pyrrolo-fused diindoles | Litcius