Controlled release of silibinin in GelMA hydrogels inhibits inflammation by inducing M2-type macrophage polarization and promotes vascularization <i>in vitro</i>
Weijian Xu, Yingjia Sun, Jia Wang, Baixiang Wang, Fanxing Xu, Zhijian Xie, Yu Wang
Abstract
. This study suggested that the Sil-GelMA hydrogels not only had an anti-inflammatory effect, but also had the potential to promote vascularization. Based on these results, the Sil-GelMA hydrogels might provide a promising prospect for prevention of dry sockets in the future.
Topics & Concepts
Self-healing hydrogelsChemistryInflammationIn vitroMacrophage polarizationMacrophageBiocompatible materialSilibininCell biologyBiophysicsBiomedical engineeringCancer researchImmunologyBiochemistryMedicineBiologyPolymer chemistryWound Healing and TreatmentsImmune cells in cancerMesenchymal stem cell research