Brain-derived CCR5 Contributes to Neuroprotection and Brain Repair after Experimental Stroke
Suning Ping, Xuecheng Qiu, Michele Kyle, Li‐Ru Zhao
Abstract
oligodendrocytes in the peri-infarct cortex were observed in the mice lacking CCR5 in the brain. These pathological changes are significantly correlated with the increased infarction size and exacerbated neurological deficits. These data suggest that brain-derived CCR5 plays a key role in neuroprotection and brain repair in the subacute phase of stroke. This study reveals a novel role of CCR5 in stroke, which sheds new light on post-stroke pathomechanism.
Topics & Concepts
NeuroprotectionStroke (engine)MedicineNeurosciencePharmacologyPsychologyPhysicsThermodynamicsNeuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanismsNerve injury and regeneration