Super-resolution imaging reveals the nanoscale organization of metabotropic glutamate receptors at presynaptic active zones
Sana Siddig, Sarah Aufmkolk, Sören Doose, Marie‐Lise Jobin, Christian Werner, Markus Sauer, Davide Calebiro
Abstract
2.1 channels and Munc-18-1, which are both essential for neurotransmitter release. These findings provide previously unknown insights into the molecular organization of GPCRs at AZs, suggesting a likely implication of a close association between mGluR4 and the secretory machinery in modulating synaptic transmission.
Topics & Concepts
Metabotropic glutamate receptorNeuroscienceResolution (logic)Glutamate receptorChemistryBiophysicsReceptorBiologyComputer scienceBiochemistryArtificial intelligenceNeuroscience and Neuropharmacology ResearchPhotoreceptor and optogenetics researchLipid Membrane Structure and Behavior