Inhibition of complement C5a receptor protects lung cells and tissues against lipopolysaccharide-induced injury via blocking pyroptosis
Renying Wang, Yunxing Wang, Lan Hu, Zhenbing Lu, Xiaoshan Wang
Abstract
studies confirmed that LPS+ATP reduced cell viability, promoted cell death, generated inflammatory factors and promoted expressions of pyroptosis-related proteins, which could be prevented by W-54011 pretreatment while intensified by C5a pretreatment. The co-treatment of C5a and W-54011 could blunt the effects of C5a on LPS+ATP-induced cytotoxicity. In conclusion, inhibition of C5a/C5aR developed protective effects against LPS-induced ALI and the cytotoxicity of Beas-2B cells, and these effects may depend on blocking pyroptosis.
Topics & Concepts
PyroptosisC5a receptorBlocking (statistics)LipopolysaccharideChemistryComplement (music)ReceptorComplement systemPharmacologyCell biologyMedicineBiologyImmunologyInflammasomeBiochemistryAntibodyComputer scienceGeneComputer networkPhenotypeComplementationInflammasome and immune disordersPneumocystis jirovecii pneumonia detection and treatmentComplement system in diseases