Orally delivered solid lipid nanoparticles of irinotecan coupled with chitosan surface modification to treat colon cancer: Preparation, in-vitro and in-vivo evaluations
Navya Ajitkumar Bhaskaran, Srinivas Reddy Jitta, Salwa, SriPragnya Cheruku, Nitesh Kumar, Lalit Kumar
Topics & Concepts
Solid lipid nanoparticleZeta potentialIn vivoBiodistributionDispersityToxicityCytotoxicityChitosanPharmacologyChemistryIrinotecanAcute toxicityEx vivoDrugIn vitroColorectal cancerNanoparticleCancerMedicineNanotechnologyMaterials scienceBiochemistryInternal medicineBiologyOrganic chemistryBiotechnologyNanoparticle-Based Drug DeliveryDrug Solubulity and Delivery SystemsCancer therapeutics and mechanisms