Computational neuroscience: a frontier of the 21st century
Xiao‐Jing Wang, Hailan Hu, Chengcheng Huang, Henry Kennedy, Chengyu Li, Nikos K. Logothetis, Zhong‐Lin Lu, Qingming Luo, Mu-ming Poo, Doris Y. Tsao, Si Wu, Zhaohui Wu, Xu Zhang, Douglas Zhou
Abstract
The human brain is a biological organ, weighing about three pounds or 1.4 kg, that determines our behaviors, thoughts, emotions and consciousness. Although comprising only 2% of the total body weight, the brain consumes about 20% of the oxygen entering the body. With the expensive energy demand, the brain enables us to perceive and act upon the external world, as well as reflect on our internal thoughts and feelings. The brain is actually never at ‘rest’. Brain activities continue around the clock, ranging from functions enabling human–environment interactions to housekeeping during sleep, including processes such as synaptic homeostasis and memory formation. Whereas one could argue that sciences in the last century were dominated by physics and molecular biology, in the current century one of our major challenges is to elucidate how the brain works. A full understanding of brain functions and malfunctions is likely the most demanding task we will ever have.