Lymphatic-specific intracellular modulation of receptor tyrosine kinase signaling improves lymphatic growth and function
Raghu P. Kataru, Jung Eun Baik, Hyeung Ju Park, Catherine Ly, Jinyeon Shin, Noa Schwartz, Theresa T. Lu, Sagrario Ortega, Babak J. Mehrara
Abstract
animals had an improved capacity to resolve inflammatory responses. Our findings indicate that intracellular modulation of lymphangiogenesis is effective in inducing functional lymphatic networks and has no off-target inflammatory effects.
Topics & Concepts
Lymphatic systemIntracellularReceptor tyrosine kinaseCell biologyLymphatic EndotheliumTyrosine kinaseFunction (biology)Signal transductionReceptorProto-oncogene tyrosine-protein kinase SrcBiologyCancer researchChemistryImmunologyBiochemistryLymphatic System and DiseasesSympathectomy and Hyperhidrosis TreatmentsPlanarian Biology and Electrostimulation